Manu Tuilagi will make his first Test start for England since 2014 when they take on Ireland in Dublin on Saturday.
The 24-year-old Samoan centre gets the No 12 jersey after Ben Te’o picked up a side strain at England’s camp in Portugal.
Brothers Mako and Billy Vunipola will play for England for the first time since the Test series against the Springboks in June last year.
Tom Curry and Mark Wilson will make their Six Nations debuts, having been named at openside and blindside flanker respectively.
Scrumhalf Dan Robson is set to make his England debut having been named as a substitute, while the highly-experienced Ben Youngs will start at No 9.
‘I think it is quite clear to beat Ireland you have to beat them in the contest area,’ said coach Eddie Jones. ‘They are very good at the breakdown and in the air, both those areas are a priority for us.
‘Traditionally England and Ireland games are always very close, they are tough affairs, there is a lot of emotion in the games, so our ability to finish the game strongly is going to be vital.’
England – 15 Elliot Daly, 14 Jonny May, 13 Henry Slade, 12 Manu Tuiagi, 11 Jack Nowell, 10 Owen Farrell (c), 9 Ben Youngs, 8 Billy Vunipola, 7 Tom Curry, 6 Mark Wilson, 5 George Kruis, 4 Maro Itoje, 3 Kyle Sinckler, 2 Jamie George, 1 Mako Vunipola.
Subs: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Harry Williams, 19 Courtney Lawes, 20 Nathan Hughes, 21 Dan Robson, 22 George Ford, 23 Chris Ashton.
Photo: David Rogers/Getty Images
